Bronchiolitis obliterans after allo-SCT: clinical criteria and treatment options
نویسندگان
چکیده
منابع مشابه
Bronchiolitis Obliterans After Lung Transplantation
ing lung transplantation is 71%, and 46% of trans¬ plant recipients will survive at least 5 years.1 Al¬ though infections, medication-related adverse events, and malignancies remain important compli¬ cations, prolonged survival is limited predominantly by bronchiolitis obliterans (RO), a condition that was associated with transplantation more than a decade ago.25 Data suggest that at least 50% ...
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In allo-SCT, the potential benefit of the GVL effect has always been offset by the detrimental effect of GVHD. For more than 4 decades, separation between GVHD and GVL remained challenging and has been considered the Holy Grail in the field of allo-SCT. Several direct and indirect lines of evidence already suggested a close correlation between GVHD and the risk of relapse after allo-SCT.2 Donor...
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Bronchiolitis obliterans (BO) is a major cause of allograft dysfunction in lung and heart lung transplant recipients. Clinically, progressive airflow limitation develops because of small airway obstruction. The disease has a variable course. Some patients experience rapid loss of lung function and respiratory failure. Others experience either slow progression or intermittent loss of function wi...
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Bronchiolitis obliterans organizing pneumonia (BOOP) is increasingly recognized as an important cause of diffuse infiltrative lung disease. It is a diagnostic consideration in patients with a febrile flu-like illness of a few weeks' duration and a roentgenogram showing bilateral patchy infiltrates that are not responsive to a typical course of antibiotics. It is defined as granulated tissue plu...
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Bronchiolitis fibrosa obliterans, described first by Lange in 1901, is an obliterative process of the bronchioles in which there is extensive damage to the bronchial wall involving all the constituent elements (the epithelium, elastic tissue, and muscle fibres), and the lumen is partially or totally occluded by bronchial exudate organized by fibroblasts and capillaries. The disease is extremely...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2011
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2011.161